Semantic Interoperability and Data Mining in Biomedicine is a Network of Excellence (NoE) funded by the European Commission under Framework 6. The general objective of the network is to bridge gaps in European research infrastructure and to facilitate cross-fertilisation between scientific disciplines such as computer science, system engineering and medical/clinical research. The long-term goal of the network will be the development of generic methods and tools supporting critical tasks in medical and biomedical informatics, such as, data-mining, knowledge discovery, knowledge representation, abstraction and indexing of information, semantic-based information retrieval in a complex and high-dimensional information space, and knowledge based adaptive systems for provision of decision support for dissemination of evidence based medicine. There are 26 work packages in this project. We are involved in a number of them, including the mobility programmes (WP6), the workshop/tutorial on Natural Language Processing in the Biomedical domain (WP13), the workshop/tutorial on Text Mining and Information Retrieval (WP15), the research activity on multilingual medical dictionary (WP20) and the research activity on Ontology Engineering (WP21).